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KMID : 1161420160190070645
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Journal of Medicinal Food
2016 Volume.19 No. 7 p.645 ~ p.653
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Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation
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Jensen Gitte S.
Drapeau Cassandra
Lenninger Miki
Benson Kathleen F.
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Abstract
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The goal for this study was to evaluate safety regarding anticoagulant activity and platelet activation during daily consumption of an aqueous cyanophyta extract (ACE), containing a high dose of phycocyanin. Using a randomized, double-blind, placebo-controlled study design, 24 men and women were enrolled after informed consent, and consumed either ACE (2.3?g/day) or placebo daily for 2 weeks. The ACE dose was equivalent to ∼1?g phycocyanin per day, chosen based on the highest dose Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration. Consuming ACE did not alter markers for platelet activation (P-selectin expression) or serum P-selectin levels. No changes were seen for activated partial thromboplastin time, thrombin clotting time, or fibrinogen activity. Serum levels of aspartate transaminase (AST) showed a significant reduction after 2 weeks of ACE consumption (P?
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KEYWORD
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anticoagulant activity, blood pressure, chronic pain, liver enzymes, platelet, P-selectin
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